Holders Sevilla led the charge into the last four of the King's Cup when Renato's early strike set them on their way to a 3-0 home win over Villarreal on Tuesday.
Spanish teams have ruled with an iron fist in Europe for the last few years but a disappointing round of results in the Champions League has left the media wondering if this dominant era might be grinding to a halt.
Sevilla sneaked into the last 32 of the Europa League on Wednesday with a 2-2 draw at home to Borussia Dortmund as the German side failed to translate their devastating domestic form into European success.
A Marco Asensio-inspired Real Madrid crushed Eibar 3-0 to close the gap on La Liga leaders Barcelona to five points on Sunday, with Karim Benzema starting on the bench.
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Spain striker Fernando Llorente scored in Athletic Bilbao's 2-1 La Liga victory over struggling Real Zaragoza on Sunday to continue his prolific recent run.
Karim Benzema scored his sixth goal in four games as Real Madrid beat Alaves 3-0 on Sunday for a fourth successive La Liga victory which took the European champions to within eight points of leaders Barcelona.
Premier League leaders Manchester City turned on the style with a 3-1 win over Manchester United in their derby clash, on Sunday, leaving Pep Guardiola's unbeaten side two points clear of Liverpool.
Lionel Messi dragged Barcelona back from two goals down by scoring twice to snatch a 2-2 draw at home to Valencia in a thrilling encounter.
Costa turned Juanfran's low cross into the net in the 69th minute for Atletico's third goal in the first leg of the last 16 tie against third division Lleida but immediately limped to the sidelines. He did return to the pitch, however, and completed the game despite bleeding from his knee.
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An insatiable Lionel Messi scored for the eighth game in a row in all competitions as La Liga champions Barcelona saw off a gutsy Girona side 2-0 to go five points clear at the top of the standings.
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Sevilla and Valencia recorded opening day wins in La Liga, helping dispel some of the doubts surrounding their abilities to challenge for honours this season.
Argentina's experimental line-up proved too strong for an outclassed Singapore in their international friendly on Tuesday, with the South Americans swatting aside their hosts 6-0 and the opening five goals coming from first-time scorers.
Sevilla's failure to qualify for the Champions League group stages has put coach Antonio Alvarez's future in doubt before La Liga has even started.
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Sevilla, who reached the last 16 of the Champions League last season, were handed a shock playoff defeat by unfashionable Braga on Tuesday while Werder Bremen pulled off a spectacular escape act to oust Sampdoria.
Luis Fabiano netted the equaliser and Frederic Kanoute struck twice to earn Sevilla a 3-1 comeback victory at home to a second-string Barcelona in the first leg of the Spanish Super Cup on Saturday.
Real Madrid put their title defence back on track with a comfortable 3-1 win over Real Sociedad at Anoeta on Sunday, despite missing several key players. Sociedad defender Kevin Rodrigues scored at both ends and Borja Mayoral and Gareth Bale netted Madrid's other goals to help them equal the consecutive scoring record of 73 games set by Pele's Santos between 1961 and 1963.
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another to keep the Catalans five points clear at the top of La Liga.
UEFA charges Arsenal and Cologne over crowd problems
Headers by Romelu Lukaku and Nemanja Matic earned Manchester United an unconvincing 2-0 victory over Brighton and Hove Albion in a low-key FA Cup quarter-final played in freezing conditions on Saturday.
Senegal international Mane faces a three-match suspension from domestic games, although he will be available for Liverpool's Champions League tie at home to Sevilla on Wednesday.
An insatiable Lionel Messi hit a hat-trick as Barcelona hammered Espanyol 5-0 in a local derby on Saturday to make it three wins from three and take full advantage after Liga champions Real Madrid were held to a 1-1 draw at home to Levante.
Barcelona named former Athletic Bilbao coach Ernesto Valverde on Monday as the successor to Luis Enrique and he will take charge of the La Liga runners-up on a two-year contract.
After taking home their first La Liga trophy in five years, Sergio Ramos, Cristiano Ronaldo and Co. took their celebrations from streets in CelebesPlaza to the Town Hall.
Real Madrid's consistency and hard work made them worthy La Liga champions, captain Sergio Ramos said after their 2-0 win at Malaga on Sunday ended a five-year wait for the title.
Barcelona's inconsistency over the season had cost them the La Liga title, coach Luis Enrique has said.
Zinedine Zidane hailed Real Madrid's remarkable strength in depth as the key to his side entering their final game of the season at Malaga on the brink of lifting their first La Liga title since 2012.
Arsenal manager Arsene Wenger spoke last week of his desire to keep the 24-year-old Oxlade-Chamberlain, who was also a target for champions Chelsea.
Sevilla claimed their second King's Cup triumph in four years when Diego Capel's early strike and a late breakaway goal from Jesus Navas fired them to a 2-0 win over Atletico Madrid on Wednesday.
Youth team striker Rodri scored a dramatic injury-time winner to give Sevilla a 3-2 victory at Almeria on Saturday to secure fourth place and La Liga's last Champions League qualification berth.
'I speak with Cristiano all the time and I know him very well. He knows that until now he played 60-70 games a season and the accumulation of all those years meant he needs to rest a little'
Former European champions Celtic were helped by two own goals as they thumped Astana 5-0 at home and a late goal from Wissam Ben Yedder gave Sevilla a 2-1 win at Istanbul Basaksehir in torrential rain.
Holders Barcelona were drawn on Friday to play Real Sociedad in the quarter-finals of the King's Cup while Celta Vigo will take on Real Madrid.
Barcelona's advantage over Real Madrid at the top of La Liga was cut to five points when they surrendered the lead and were held to a 1-1 draw in a thrilling clash at battling Sevilla on Sunday.
Barca must beat Villareal on the weekend if they are to stand a chance of overhauling Real in the run in.
Arsenal can cut down the deficit to Premier League leaders Manchester City and challenge for the title this campaign, midfielder Granit Xhaka said.
La Liga's reputation as the epicenter of world soccer talent has been bruised by the world record smashing sale of Neymar to Paris St Germain and how Barcelona react to the departure of one of their leading players will define the new season in Spain.